The nascent mining sector in Malawi presents an opportunity to intervene early and establish necessary systems and services to manage the burden of disease from mining. However, Malawi has ex-miners and active miners who worked in Zimbabwe and South Africa. Preliminary analysis of MDR-TB cases shows that at least 50 percent of drug-resistant cases in Malawi can be traced to South Africa. Just like regional peers, Malawi has a high TB-HIV coinfection rate, which makes its TB burden complex to manage.